Skin examines the relationship between artist Ex de Medici, equally renowned for her vivid paintings and her groundbreaking tattooing, and Geoff Ostling, an overweight 65-year-old whose body has been etched with a tapestry of flowers by Ex's needles and ink. Now entirely tattooed, Geoff is forced to confront his mortality as he and Ex undertake to have Geoff's skin preserved and exhibited after he dies.